Table I.

Distribution of causal SNPs by sample

Gene	Trait	Chromo some	Number of SNPsa	CCb	F1c	F2	F3	F4	F5	F6	F7	F8
AKT3	DXd	1	1	1	0	0	0	0	0	0	0	2
ARNT	Q1	1	5	23	3	2	0	0	6	0	0	0
BCHE	Q2	3	13	19	4	0	0	0	1	0	2	2
BCL2L11	DX	2	3	6	0	0	0	0	0	2	0	0
ELAVL4	Q1, DX	1	2	2	0	0	1	0	0	0	0	0
FLT1	Q1	13	11	170	0	0	5	0	28	16	13	12
FLT4	Q1	5	2	3	0	0	0	0	0	0	0	0
GCKR	Q2	2	1	17	2	0	0	0	0	0	0	0
HIF1A	Q1	14	4	22	0	0	0	0	1	0	0	0
HIF3A	Q1	19	3	3	0	0	0	0	3	0	0	0
HSP90AA1	DX	14	4	367	61	78	74	64	59	65	115	60
INSIG1	Q2	7	3	3	0	0	0	0	0	0	0	0
KDR	Q1	4	10	271	14	37	43	31	6	0	93	0
LPL	Q2	8	3	25	7	20	2	1	0	1	23	7
NRAS	DX	1	1	1	0	0	0	0	0	0	0	0
PDGFD	Q2	11	4	16	0	0	0	0	0	0	2	0
PIK3C2B	DX	1	24	62	3	4	8	0	4	6	9	0
PIK3C3	DX	18	2	25	0	0	0	0	2	0	5	0
PIK3R3	DX	1	1	1	0	0	0	0	0	0	0	0
PLAT	Q2	8	8	23	0	1	2	0	0	3	0	0
PRKCA	DX	17	2	233	53	57	70	51	29	47	48	60
PRKCB1	DX	16	1	1	0	0	0	0	0	0	0	0
PTK2	DX	8	2	2	0	0	0	0	0	0	0	0
PTK2B	DX	8	3	5	0	0	0	0	0	0	0	0
RARB	Q2	3	2	8	0	0	0	0	0	0	0	0
RRAS	DX	19	2	4	0	0	0	0	0	2	1	0
SHC1	DX	1	1	9	0	0	0	0	0	0	0	0
SIRT1	Q2	10	8	12	0	0	3	0	0	4	21	0
SOS2	DX	14	2	6	0	0	0	0	0	0	0	0
SREBF1	Q2	17	10	31	16	21	0	5	9	12	8	0
VEGFA	Q1	6	1	3	4	20	0	0	0	0	22	0
VEGFC	Q1	4	1	1	0	0	0	0	0	0	31	0
VLDLR	Q2	9	8	14	2	0	0	0	11	0	6	0
VNN1	Q2	6	2	246	35	60	27	15	24	17	77	0
VNN3	Q2	6	7	201	24	17	27	0	21	0	42	42
VWF	Q2	12	2	9	0	0	0	2	0	0	0	0

^aNumber of variants within the gene that influence the trait.

^bNumber of causal variants observed in the unrelated sample.

^cF1 to F8 are the number of causal variants observed in each family (Family 1 through Family 8).

^dDX is diagnosis, that is, presence or absence of a discrete phenotype.