A, Tx Protocol 2: Groups similar to Tx Protocol 1 except that 1018 ISS was given for 12 weeks, followed by either 4 (B) or 13 (C) weekly RW only exposures. BALF cytokines, eosinophils, and lung gene expression shown (mean ± SEM, 5 mice/group). *P<0.05, **P<0.01, and ***P<0.0001, compared to RW. 1 representative experiment of 4 shown.