Table 5.
Metabolism
| Gene | Protein name | Expression in EO | Pathway/Function | Disrupted phenotype | Reference |
|---|---|---|---|---|---|
| acsbg2 | acyl-CoA synthetase bubblegum family member 2 | - | Fatty acid metabolism | ||
| acsl3b | acyl-CoA synthetase long-chain family member 3b | + | Fatty acid metabolism | ||
| acy1 | Aminoacylase-1 | - | Aminoacids metabolism | ||
| adssl1 | adenylosuccinate synthase like 1 | - | Purine metabolism | ||
| aldoab | Fructose-bisphosphate aldolase | - | Glycolysis | ||
| ampd1 | Adenosine monophosphate deaminase 1 (Isoform M) | - | Purine metabolism | ||
| aoc2 | amine oxidase, copper containing 2 | + | beta-Alanine metabolism | ||
| cds1 | CDP-Diacylglycerol Synthase 1 | + | Glycerophospholipid biosynthesis | Imperfect angiogenesis | [56] |
| ckma | creatine kinase, muscle a | - | Metabolism of amino acids and derivatives | ||
| ckmt2a | creatine kinase, mitochondrial 2a (sarcomeric) | - | Metabolism of amino acids and derivatives | ||
| cox4i2 | cytochrome c oxidase subunit IV isoform 2 | - | Oxidative phosphorylation | ||
| cpt2 | carnitine palmitoyltransferase 2 | + | Fatty acid beta-oxidation | ||
| cyp24a1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | - | Steroid biosynthesis | ||
| dhrs9 | dehydrogenase/reductase (SDR family) member 9 | + | Retinol metabolism | ||
| gdpd4a | glycerophosphodiester phosphodiesterase domain containing 4a | + | Glycerol metabolism | ||
| gdpd5a | glycerophosphodiester phosphodiesterase domain containing 5a | + | Glycerol metabolism | ||
| gdpd5b | glycerophosphodiester phosphodiesterase domain containing 5b | + | Glycerol metabolism | ||
| glo1 | Glyoxalase 1 | - | Pyruvate metabolism | ||
| glud1b | glutamate dehydrogenase 1b | - | Nitrogen metabolism | ||
| got2a | glutamic-oxaloacetic transaminase 2a, mitochondrial | - | Glucose metabolism; aminoacids metabolism | ||
| gpib | glucose-6-phosphate isomerase b | - | Gluconeogenesis | ||
| idi1 | isopentenyl-diphosphate delta isomerase 1 | - | Cholesterol biosynthesis | ||
| man1a1 | mannosidase, alpha, class 1A, member 1 | + | N-Glycan biosynthesis | ||
| me3 | malic enzyme 1, NADP(+)-dependent, cytosolic | - | Pyruvate metabolism | ||
| pcyox1 | prenylcysteine oxidase 1 | - | Terpenoid backbone biosynthesis | ||
| pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | - | Glycolysis | ||
| pgam2 | phosphoglycerate mutase 2 (muscle) | - | Glycolysis and Gluconeogenesis | ||
| pgm5 | Phosphoglucomutase 5 | - | Glucuronidation | Failure in myofibril assembly | [57] |
| ucp3 | uncoupling protein 3 | - | Respiratory electron transport | ||
| ugp2b | UDP-glucose pyrophosphorylase 2b | - | Glucose metabolism | ||
| gyg1a | glycogenin 1a | - | Glycogen Metabolism | ||
| mid1ip1l | MID1 interacting protein 1, like | - | lipid metabolic process |
For each of the shared differentially expressed gene are reported: the gene and protein names obtained from the top hit blast results against the proteome of D. rerio; whether it is up(+)- or down(−)- regulated in the EO; its function or pathway (or both when available); the phenotypic effect on D. rerio of its mis-expression (when available)