Table 6.
Transcription factors
| Gene | Protein name | Expression in EO | Pathway/Function | Disrupted phenotype | Reference |
|---|---|---|---|---|---|
| eng1b | engrailed homeobox 1b | + | neuron fate commitment | ||
| her6 | hairy-related 6 | + | Notch signaling pathway | ||
| hes6 | hes family bHLH transcription factor 6 | + | Notch signaling pathway | ||
| hey1 | hes-related family bHLH transcription factor with YRPW motif 1 | + | Notch signaling pathway | ||
| hipk2 | homeodomain interacting protein kinase 2 | + | Wnt signaling pathway; p53 Signaling; ERK Signaling | Induced apoptosis | [58] |
| hoxc11a | homeobox C11a | + | |||
| hoxd11a | homeobox D11a | + | |||
| mef2aa | myocyte enhancer factor 2aa | + | Signaling by FGFR | Abnormal development of posterior somites | [29] |
| mef2b | myocyte enhancer factor 2b | + | miRs in Muscle Cell Differentiation | ||
| rb1 | retinoblastoma 1 | + | E2F mediated regulation of DNA replication; Cell cycle | Abnormal retina development | [59] |
| taf6 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor | + | GPCR Pathway | ||
| arxa | aristaless related homeobox a | - | Axon guidance | Abnormal dopaminergic neurons development | [60] |
| klf15 | Kruppel-like factor 15 | - | Adipogenesis | ||
| pbxip1 | pre-B-cell leukemia homeobox interacting protein 1 | - | |||
| myf6 | myogenic factor 6 | - | Myogenesis | Disrupted myogenesis | [28] |
| myog | myogenin | - | Myogenesis | Disrupted myogenesis | [27] |
| nfatc1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | - | Wnt signaling pathway | ||
| nr0b2a | nuclear receptor subfamily 0, group B, member 2a | - | Nuclear Receptor transcription pathway; NOD-like Receptor Signaling Pathways | ||
| pitx2 | paired-like homeodomain 2 | - | retinoic acid receptor signaling pathway | Abnormal eye and craniofacial development | [61] |
| rxrgb | retinoid X receptor, gamma b | - | steroid hormone receptor activity; retinoic acid receptor signaling pathway | ||
| six1b | SIX homeobox 1b | - | regulation of skeletal muscle cell proliferation | Abnormal trunk musculature development | [62] |
| six4b | SIX homeobox 4b | - | regulation of skeletal muscle cell proliferation | ||
| tbx15 | T-box 15 | - | regulation of transcription, DNA-templated |
For each of the shared differentially expressed gene are reported: the gene and protein names obtained from the top hit blast results against the proteome of D. rerio; whether it is up(+)- or down(−)- regulated in the EO; its function or pathway (or both when available); the phenotypic effect on D. rerio of its mis-expression (when available)