Table 7.
Cross-species differentially expressed genes with known phenotypic effect
| Gene | Protein | Tissue | Sub-cluster | Phenotype | Source |
|---|---|---|---|---|---|
| nme2b.2 | NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2 | SM | 4 | GTP biosynthesis | ZFIN |
| prkcg | protein kinase C, gamma | EO | 1 | AMPA-R kinetics | ZFIN |
| aco2 | aconitase 2, mitochondrial | EO | 2 | Infantile cerebellar-retinal degeneration | OMIM |
| pdp1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | EO | 2 | Pyruvate dehydrogenase phosphatase deficiency | OMIM |
| nnt | nicotinamide nucleotide transhydrogenase | EO | 2 | Glucocorticoid deficiency 4 | OMIM |
| sucla2 | succinate-CoA ligase, ADP-forming, beta subunit | EO | 2 | Mitochondrial DNA depletion syndrome 5 | OMIM |
| kcnj11 | potassium inwardly-rectifying channel, subfamily J, member 11 | EO | 2 | Diabetes mellitus | OMIM |
| ippk | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | EO | 2 | Craniofacial development | ZFIN |
| smpd1 | sphingomyelin phosphodiesterase 1, acid lysosomal | EO | 2 | Niemann-Pick disease | OMIM |
| th | tyrosine hydroxylase | EO | 2 | Adult brain function | ZFIN |
| ache | acetylcholinesterase | EO | 2 | Locomotion | ZFIN |
| oxct1a | 3-oxoacid CoA transferase 1a | EO | 2 | Succinyl CoA:3-oxoacid CoA transferase deficiency | OMIM |
| mlycd | malonyl-CoA decarboxylase | EO | 2 | Malonyl-CoA decarboxylase deficiency | OMIM |
| idh1 | isocitrate dehydrogenase 1 (NADP+), soluble | EO | 2 | Susceptibility to glioma | OMIM |
| cpt2 | carnitine palmitoyltransferase 2 | EO | 2 | Myopathy/Encephalopathy | OMIM |
| pltp | phospholipid transfer protein | EO | 2 | HDL cholesterol level | OMIM |
| acat1 | acetyl-CoA acetyltransferase 1 | EO | 2 | Alpha-methylacetoacetic aciduria | OMIM |
| atp1a1a.1 | ATPase, Na+/K+ transporting, alpha 1a polypeptide, tandem duplicate 1 | EO | 3 | Brain development | ZFIN |
| ryr1a | ryanodine receptor 1a (skeletal) | EO | 3 | Myopathy | ZFIN |
| bcl2l10 | BCL2-like 10 (apoptosis facilitator) | EO | 3 | Cytoskeletal activity | ZFIN |
| nalcn | sodium leak channel, non-selective | EO | 3 | Hypotonia | OMIM |
| cngb1a | cyclic nucleotide gated channel beta 1a | EO | 3 | Retinitis pigmentosa 45 | OMIM |
| kcnma1a | potassium large conductance calcium-activated channel, subfamily M, alpha member 1a | EO | 3 | Hearing sensitivity | ZFIN |
| kcnq5b | potassium voltage-gated channel, KQT-like subfamily, member 5b | EO | 3 | Cell membrane excitability | ZFIN |
| nsfa | N-ethylmaleimide-sensitive factor a | EO | 3 | Axon development | ZFIN |
| chrna4b | cholinergic receptor, nicotinic, alpha 4b | EO | 3 | Epilepsy | OMIM |
| adcy1b | adenylate cyclase 1b | EO | 3 | Deafness | OMIM |
| actn2b | actinin, alpha 2b | EO | 3 | Cardiomyopathy | OMIM |
| vmhc | ventricular myosin heavy chain | EO | 3 | Cardiomyopathy | OMIM |
List of cross-species differentially expressed genes belonging to the terms obtained from the enrichment analysis. For each gene, we report: the analysed tissue; the relative sub-cluster as reported in Figs. 6 or 7; and the phenotypic effect of gene function disruption on D. rerio (ZFIN) or Homo sapiens (OMIM)