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. 2014 Aug 15;16(4):4225. doi: 10.1186/s13075-014-0411-6

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© Tsou et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of dihydrolipoic acid on the platelet-derived growth factor receptor pathway and phosphatases. (A) Phosphorylated platelet-derived growth factor receptor (p-PDGFR) after PDGF stimulation at various time points (n = 3 NL and SSc subjects). NS, Nonstimulated. Enzymatic activities of protein tyrosine phosphatase 1B (PTP1B) (B), Src homology 2 domain–containing protein tyrosine phosphatase 2 (SHP-2) (C) and density-enhanced phosphatase 1 (DEP-1) (D) in fibroblasts with or without dihydrolipoic acid (DHLA) or N-acetylcysteine (NAC). Results are expressed as mean ± SEM. P < 0.05 was considered significant.