Table 3.
Treatment outcomes for SSRIs in combination with the different NSAID groups and selected NSAIDs
| Contacts with depression | Any Psychiatric Contacts | Suicide Attempts | |||||||
|---|---|---|---|---|---|---|---|---|---|
| N (events) | Person-Years | Adjusted* HRR (95%-CI) | N (events) | Person-Years | Adjusted* HRR (95%-CI) | N (events) | Person-Years | Adjusted* HRR (95%-CI) | |
| SSRI only | 2966 | 46,136.5 | 1.0 | 5823 | 42,710.5 | 1.0 | 837 | 44,900.8 | 1.0 |
| Salicylates | 83 | 2653.8 | 0.77 (0.57; 1.03) | 117 | 2651.4 | 0.75 (0.59; 0.95) | 9 | 2662.4 | 0.59 (0.25; 1.40) |
| ASA | 15 | 369.5 | 1.02 (0.55; 1.90) | 16 | 303.7 | 1.03 (0.61; 1.75) | <4^ | - | - |
| ASA low-dose | 61 | 2184.3 | 0.71 (0.50; 1.01) | 88 | 2182.2 | 0.74 (0.56; 0.98) | 6 | 2192.2 | 0.38 (0.12; 1.26) |
| Non-sel. NSAIDs | 46 | 1203.3 | 0.78 (0.56; 1.08) | 137 | 1197.4 | 1.12 (0.94; 1.35) | 18 | 1205.1 | 0.99 (0.60; 1.64) |
| Ibuprofen | 43 | 956.1 | 0.92 (0.65; 1.29) | 81 | 954.1 | 0.76 (0.60; 0.98) | 15 | 958.0 | 1.07 (0.62; 1.87) |
| Naproxen | <4^ | - | - | 50 | 100.8 | 4.70 (3.51; 6.29) | <4^ | - | - |
| Non-sel. COX | 92 | 698.4 | 3.31 (2.64; 4.16) | 114 | 697.5 | 1.90 (1.53; 2.37) | 9 | 700.3 | 0.96 (0.45; 2.04) |
| Diclofenac | 83 | 423.0 | 4.47 (3.58; 5.59) | 99 | 422.2 | 2.60 (2.07; 3.27) | 5 | 424.5 | 0.78 (0.29; 2.10) |
| Selective COX-2 | 11 | 242.5 | 1.33 (0.64; 2.78) | 25 | 241.5 | 2.17 (1.37; 3.44) | 5 | 242.9 | 3.20 (1.18; 8.72) |
| Celecoxib | 8 | 113.6 | 1.74 (0.70; 4.30) | 22 | 112.6 | 3.84 (2.40; 6.13) | 5 | 114.0 | 5.09 (1.65; 15.72) |
Abbreviations and explanations: HRR=Hazard rate ratio; 95%-CI=95% Confidence Interval; ASA=acetylsalicylic acid; NSAID = nonsteroidal anti-inflammatory drug; COX = Cyclooxygenase; SSRI = Selective serotonin reuptake inhibitor; Bold numbers represent statistically significant results.
The results are adjusted for: Age; gender; educational level; previous contacts with psychiatric and somatic disorders; Charlson Index score; prior use of NSAIDs, paracetamol, other anti-inflammatory and GI-protective drugs within the preceding year to index date; SSRI start year and earlier suicide attempts. ^Number of less than 4 are not reportable due to data protection.