Fig 4.

A-F, Baseline mitochondrial respiration determined by measuring OCR and the effect of MitoQ on TGF-β ± FBS–induced DNA synthesis were determined in ASM cells from healthy subjects (Fig 4, A and B), smokers (Fig 4, C and D), and patients with COPD (Fig 4, E and F). G and H, Effects of Tiron on TGF-β ± FBS–induced DNA synthesis (Fig 4, G) and MitoQ on TNF-α–induced CXCL8 release (Fig 4, H) were determined. Bars represent means ± SEMs of 3 (Fig 4, A, C, E, G, and H), 8 (Fig 4, B), 6 (Fig 4, D), and 4 (Fig 4, F) donors. *P < .05, **P < .01, and ***P < .001.