Fig. 3.

5hmC densities on chromosomes, within genomic features, and around histone modification binding sites. a 5hmC density remained relatively stable from one chromosome to the next, although the density appeared to show more variability on shorter chromosomes. 5hmC density was also far greater on autosomal chromosomes than the two sex chromosomes (two-tailed P < 0.0001). b 5hmC was most highly abundant in enhancer elements and gene bodies, while its density decreased in CpG islands, the TSS, and repetitive elements. c Increased 5hmC was observed at the H3K4me1 binding site, while the opposite was true for both H3K4me3 and H3K27ac binding sites