Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 3;16(1):672. doi: 10.1186/s12864-015-1875-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Gross et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — 5hmC was enriched in the gene bodies of highly expressed genes and at exon-intron boundaries. a 5hmC density was plotted against genomic location for all genes separated in quartiles by their expression levels. 5hmC showed the greatest decrease in density at the TSS for highly expressed genes, while also showing the greatest increase in density in the gene body for this same group. The opposite trend was seen in genes in the lowest quartile of expression. An interesting spike in 5hmC density was also observed at the TES in all quartiles of expression. b 5hmC density is increased in the exons on the 5’ and 3’ ends of exon-intron boundaries. c A similar pattern of 5hmC density was also seen on the anti-sense strand of corresponding exon-intron boundaries. (TSS = transcription start site; TES = transcription end site)