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. Author manuscript; available in PMC: 2015 Sep 3.
Published in final edited form as: Behav Brain Res. 2011 Aug 18;227(2):410–417. doi: 10.1016/j.bbr.2011.08.002

Fig. 1.

Fig. 1

Stroke induces a multilineage response from adult SVZ. Nestin-CreERT2 :YFP mice were used to fate map nestin+ derivatives following stroke [12]. (A) Confocal images of YFP+ cells that populate the ischemic striatum by 2-weeks following 60 min transient MCAO. Phenotypic fate mapping was performed using markers for migrating neuroblasts (DCX), oligodendrocyte lineage (Olig2) and astrocytes (GFAP). Scale bars = 100 μm (YFP only and YFP/GFAP images), 20 μm (YFP/DCX and YFP/Olig2 images). (B) At 6-weeks post-MCAO, the relative distribution of YFP+ cells within the ischemic brain parenchyma includes approximately 45% astrocytes, 20% oligodendrocyte progenitors (OPCs), 20% neuroblasts and 5% postmitotic neurons.