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Kinetics of 7-DHC/cholesterol in the brain (A), spinal cord (B) and sciatic nerve (C) of SLOS mice. For each time point, the ratio is an average of 6 animals and the bars represent the standard error of the mean (SEM). A higher 7-DHC/cholesterol ratio is indicative of a greater biochemical imbalance. This ratio is very low (close to zero) in normal mice and does not change with age.
