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Partial normalization of cholesterol metabolism in sciatic nerve. Ratios of DHC/cholesterol in the sciatic nerve of SLOS mice treated IT with AAV-DHCR7 (n = 11), or saline (n = 5) and their normal littermates (n = 6) were compared. Tissues were collected 8 weeks after treatment of 3-day old mice, DHC is the sum of 7-DHC and 8-DHC, and the non-parametric Mann–Whitney test was used for statistical analysis.
