Table 1.

The functional analysis of the DEGs

Category	GO ID	Name	Count	p-value
A: the top 5 GO terms of the up-regulated DEGs
BP	GO:0001775	cell activation	68	<1.00E-16
BP	GO:0002253	activation of immune response	48	<1.00E-16
BP	GO:0002376	immune system process	165	<1.00E-16
BP	GO:0002682	regulation of immune system process	94	<1.00E-16
BP	GO:0002684	positive regulation of immune system process	73	<1.00E-16
CC	GO:0005576	extracellular region	138	<1.00E-16
CC	GO:0005615	extracellular space	70	<1.00E-16
CC	GO:0044421	extracellular region part	86	<1.00E-16
CC	GO:0071944	cell periphery	191	2.64E-14
CC	GO:0005886	plasma membrane	186	1.49E-13
MF	GO:0008009	chemokine activity	10	2.35E-07
MF	GO:0003823	antigen binding	12	4.64E-07
MF	GO:0032403	protein complex binding	26	4.85E-07
MF	GO:0042379	chemokine receptor binding	10	1.11E-06
MF	GO:0005178	integrin binding	12	1.41E-06
B: the top 5 GO terms of the down-regulated DEGs
BP	GO:0043588	skin development	311	2.33E-14
BP	GO:0008544	epidermis development	280	1.18E-12
BP	GO:0030216	keratinocyte differentiation	108	1.09E-09
BP	GO:0009913	epidermal cell differentiation	154	1.01E-08
BP	GO:0009888	tissue development	1479	2.09E-08
CC	GO:0030057	desmosome	22	5.73E-06
CC	GO:0005882	intermediate filament	191	2.33E-05
CC	GO:0045111	intermediate filament cytoskeleton	231	2.76E-05
CC	GO:0045095	keratin filament	93	0.00096928
CC	GO:0005911	cell-cell junction	297	0.00108577
MF	GO:0005198	structural molecule activity	627	2.89E-05
MF	GO:0005200	structural constituent of cytoskeleton	94	0.00104197
MF	GO:0016755	transferase activity, transferring amino-acyl groups	24	0.003031659
MF	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	25	0.003414279
MF	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	26	0.003825148

MF molecular function, BP biological process, CC cell component