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. 2015 Sep 4;12:156. doi: 10.1186/s12974-015-0374-9

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© Zhang et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Methamphetamine mediates the activation of the Src/ERK MAPK pathway. Methamphetamine induced a Src phosphorylation and b ERK phosphorylation in a time-dependent manner in C6 cells. c σ-1R was expressed in C6 cells. d Pretreatment of C6 cells with the σ-1R antagonist (BD1047; 10 μM) inhibited methamphetamine-induced expression of p-Src. e Pretreatment of C6 cells with the σ-1R antagonist (BD1047; 10 μM) or the Src inhibitor (PP2; 10 μM) inhibited methamphetamine-induced expression of p-ERK. Representative immunoblots and the densitometric analysis of p-Src/t-Src from three separate experiments are presented. All the data are presented as the mean ± SD of three individual experiments. *p < 0.05 and **p < 0.01 compared with control group; #p < 0.05 compared with methamphetamine-treated group