Table 5.
Acne lesion count (ALC) and global acne grading system (GAGs) and response
| Dose level | ALC baseline/cycle 1/cycle 2 | GAGs baseline/cycle 1/cycle 2 | CTCAE V3.0 grade of rash cycle 1/cycle 2 | Best response |
|---|---|---|---|---|
| 0 | 0/149 | 0/22 | 2 | PD |
| 0 | 0/301/275 | 0/32/33 | 2/2 | SD |
| 0 | 0/46 | 0/23 | 2 | PD |
| 1 | 0 | 0 | 0 | PD |
| 1 | 0 | 0 | 1 | PD |
| 1 | 0/69/119 | 0/6/33 | 2/2 | SD |
| 2 | 0/59 | 0/27 | 2 | NE |
| 2 | 159/998/1773 | 9/33/33 | 3/3 | PD |
| 2 | 0/137/418 | 0/33/33 | 2/2 | PD |
| 3 | 0/67 | 0/27 | 2 | PD |
| 3 | 0 | 0 | 2 | SD |
| 3 | 0/0 | 0/0 | 2 | PD |
| 3 | 0/83 | 0/24 | 2 | PD |
| 3 | 0/223 | 0/21 | 2 | PD |
| 3 | 0/26 | 0/2 | 2 | PD |
| 3 | 0 | 0 | 1 | SD |
| 3 | 0/20 | 0/24 | 1 | PD |
| 3 | 0 | 0 | 1 | PD |
| 3 | 0/36 | 0/21 | 2 | SD |
| 3 | 0/3 | 0/3 | 2 | NE |
| 3 | 0 | 0 | 0 | NE |
| 3 | 0/216 | 0/27 | 1 | NE |
| 3 | 0/0 | 0/0 | 0 | SD |
| 3 | 0/87 | 0/33 | 2 | SD |