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. 2015 Sep 4;12:27. doi: 10.1186/s12989-015-0102-8

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© Disdier et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Representative images of immunofluorescence expression of tight junction protein claudin-5 (red) and endothelial cell marker vonWillebrand factor (vWF, green) in the cerebral microvasculature of (a) control rats, or tissues collected from rats treated with 1 mg/kg TiO₂ (IV) at (b) 5 min; (c) 6 h; (d) 24 h or (e) 28 days post-treatment. Yellow fluorescence indicates overlay (co-localization) of claudin-5 and vWF. Arrows indicate areas of increased yellow fluorescence. Graph in (f) shows analysis of relative fluorescence of overlay images ± SD. *P < 0.050 compared to controls