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. 2015 Sep 4;12:27. doi: 10.1186/s12989-015-0102-8

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© Disdier et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — BBB integrity assessment. The integrity was estimated by the ratio between atenolol concentrations in brain and plasma (partition coefficient or Kp) at 6 h, 24 h, 7 days and 28 days after IV administration. Each data point represents the mean ± SD of n = 4 rats. Statistical comparison was performed by two-way ANOVA