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. 2015 Sep 4;12:27. doi: 10.1186/s12989-015-0102-8

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© Disdier et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — mRNA expression of cytokines and chemokines in isolated brain microvasculature endothelial cells and parenchyma fraction after IV injection of 1 mg/kg TiO₂ NPs in rats. mRNA transcription profiles for IL-1β, IP-10 and CXCL1 in isolated rat brain microvasculature endothelial cells and IL6 in parenchyma fractions of control and treated animals performed by RT-qPCR at 24 h (a) and 28 days (b) after IV injection. Each data point represents the mean ± SEM of n = 4 animals and RT-qPCR were performed in duplicate for each single preparation of brain microvasculature endothelial cells. Statistical comparison was performed by one tailed Mann Whitney test, *P < 0.05; ** P < 0.01