Table 1. Demographic and clinical characteristics among children with CHD.
Total | CAA (+) | ||||
---|---|---|---|---|---|
Variables | n | (%) | n | (Rate, %) | p b |
No. of CHD patients | 39652 | 1591 | (4.0) | ||
Gender, n (%) | <0.001 | ||||
Male | 19713 | (49.7) | 946 | (4.8) | |
Female | 19939 | (50.3) | 645 | (3.2) | |
Age at CHD diagnosis a , n (%) | <0.001 | ||||
Neonates | 22147 | (55.9) | 800 | (3.6) | |
Infants | 12797 | (32.3) | 741 | (5.8) | |
Toddlers & Preschools | 4708 | (11.9) | 50 | (1.1) | |
Median follow-up, years (IQR) | 7 | (3–9) | |||
Follow-up period, years | <0.001 | ||||
0–3 | 10624 | (26.8) | 480 | (4.5) | |
4–7 | 11223 | (28.3) | 478 | (4.3) | |
≧8 | 17805 | (44.9) | 633 | (3.6) | |
Other associated ECA, n (%) | |||||
Nervous system | <0.001 | ||||
(+) | 1183 | (3.0) | 157 | (13.3) | |
(-) | 38469 | 1434 | (3.7) | ||
Musculoskeletal system | <0.001 | ||||
(+) | 1250 | (3.2) | 202 | (16.2) | |
(-) | 38402 | 1389 | (3.6) | ||
Eyes/ears/face/neck | |||||
(+) | 475 | (1.2) | 85 | (17.9) | <0.001 |
(-) | 39177 | 1506 | (3.8) | ||
Cleft lip/palate | <0.001 | ||||
(+) | 732 | (1.8) | 110 | (15.0) | |
(-) | 8920 | 1481 | (3.8) | ||
Gastrointestinal system | <0.001 | ||||
(+) | 846 | (2.1) | 81 | (9.6) | |
(-) | 38006 | 1510 | (3.9) | ||
Urinary system | <0.001 | ||||
(+) | 540 | (1.4) | 43 | (8.0) | |
(-) | 39112 | 1548 | (4.0) | ||
Genital system | <0.001 | ||||
(+) | 742 | (1.9) | 86 | (11.6) | |
(-) | 38910 | 1505 | (3.9) | ||
Integument | 0.287 | ||||
(+) | 56 | (0.1) | 4 | (7.1) | |
(-) | 39596 | 1587 | (4.0) | ||
Chromosome | <0.001 | ||||
(+) | 1267 | (3.2) | 155 | (12.2) | |
(-) | 38385 | 1436 | (3.7) | ||
Mortality | <0.001 | ||||
(+) | 2533 | (6.4) | 199 | (7.9) | |
(-) | 37119 | 1392 | (3.8) |
Abbreviation: CHD, congenital heart disease; CAA, congenital airway anomaly; ECA, extracardiac anomaly; IQR, inter-quartile range.
aNeonate, newborn to ≤ 28 days of life; infant, >28 days but < 12 months; toddler & preschool, aged 1–5 years.
bχ2 or Fisher’s exact tests for the presence of CAA among different stratum