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. 2015 Sep 3;10(9):e0137437. doi: 10.1371/journal.pone.0137437

Table 1. Demographic and clinical characteristics among children with CHD.

Total CAA (+)
Variables n (%) n (Rate, %) p b
No. of CHD patients 39652 1591 (4.0)
Gender, n (%) <0.001
  Male 19713 (49.7) 946 (4.8)
  Female 19939 (50.3) 645 (3.2)
Age at CHD diagnosis a , n (%) <0.001
  Neonates 22147 (55.9) 800 (3.6)
  Infants 12797 (32.3) 741 (5.8)
  Toddlers & Preschools 4708 (11.9) 50 (1.1)
Median follow-up, years (IQR) 7 (3–9)
Follow-up period, years <0.001
  0–3 10624 (26.8) 480 (4.5)
  4–7 11223 (28.3) 478 (4.3)
  ≧8 17805 (44.9) 633 (3.6)
Other associated ECA, n (%)
  Nervous system <0.001
    (+) 1183 (3.0) 157 (13.3)
    (-) 38469 1434 (3.7)
  Musculoskeletal system <0.001
    (+) 1250 (3.2) 202 (16.2)
    (-) 38402 1389 (3.6)
  Eyes/ears/face/neck
    (+) 475 (1.2) 85 (17.9) <0.001
    (-) 39177 1506 (3.8)
  Cleft lip/palate <0.001
    (+) 732 (1.8) 110 (15.0)
    (-) 8920 1481 (3.8)
  Gastrointestinal system <0.001
    (+) 846 (2.1) 81 (9.6)
    (-) 38006 1510 (3.9)
  Urinary system <0.001
    (+) 540 (1.4) 43 (8.0)
    (-) 39112 1548 (4.0)
  Genital system <0.001
    (+) 742 (1.9) 86 (11.6)
    (-) 38910 1505 (3.9)
  Integument 0.287
    (+) 56 (0.1) 4 (7.1)
    (-) 39596 1587 (4.0)
  Chromosome <0.001
    (+) 1267 (3.2) 155 (12.2)
    (-) 38385 1436 (3.7)
Mortality <0.001
    (+) 2533 (6.4) 199 (7.9)
    (-) 37119 1392 (3.8)

Abbreviation: CHD, congenital heart disease; CAA, congenital airway anomaly; ECA, extracardiac anomaly; IQR, inter-quartile range.

aNeonate, newborn to ≤ 28 days of life; infant, >28 days but < 12 months; toddler & preschool, aged 1–5 years.

bχ2 or Fisher’s exact tests for the presence of CAA among different stratum