Table 4.

TBM results: regions showing gray matter (GM) loss progression in all AD patients vs. controls, and in EOAD and LOAD vs. age-matched controls.

Anatomical region	SPM coordinates			All vs. controls	EOAD vs. age-matched controls	LOAD vs. age-matched controls
	X	Y	Z	T value	T value	T value
L anterior hippocampus/parahippocam pus	−14	2	−20	4.86°	4.21° (−14,−16,−20)	-
R parahippocampus	20	−14	−28	5.39*	-	4.84°
R hippocampus tail	16	−36	6	3.59°	-	4.26°(20,−32,8)
L amygdala	−34	2	−22	4.49°	3.57°(−32,2,−20)	-
L precuneus	−2	−60	18	6.29*	4.74° (0,−62,18)	4.49° (−6,−60,20)
L PCC	−2	−40	34	5.61*	3.89° (2,−42,30)	4.35° (−4,−42,34)
L inferior parietal lobule	−54	−48	46	3.95°	-	3.51°(−54,−34,42)
L posterior middle temporal gyrus	−64	−30	−10	4.47°	3.69°(−68,−40,0)	-
R posterior middle temporal gyrus	48	−58	20	-	-	3.49°
L anterior middle temporal gyrus	−58	−10	−20	5.46*	-	5.29* (−56,−12,−20)
R inferior temporal gyrus	−56	−26	−22	4.60°	3.86° (68,−34,−22)	4.05° (50,−24,−30)
L fusiform gyrus	−38	−12	−32	3.97°	-	3.99°(−36,−14,−32)
L middle occipital	−38	−76	20	3.25°	-	3.90°(−38,−70,36)
R rectus gyrus	8	24	−22	-	-	3.44°
L superior medial frontal gyrus	2	36	40	4.64°	3.69°	-
R SMA	2	4	58	-	3.34°	-
L medial orbito-frontal gyrus	−2	52	−2	4.67°	-	3.73°(0,50,−6)
L IFG	−36	16	26	-	-	3.60°

^*p <0.05 (FWE),

^°p <0.001 uncorrected.

Abbreviations: EOAD= early onset Alzheimer Disease, IFG= inferior frontal gyrus, LOAD= late onset Alzheimer Disease, PCC= posterior cingulate cortex, SMA= supplementary motor area, SPM= Statistical Parametric Mapping.