Table 1.
Baseline characteristics of included population, by systolic BP group
| Population Characteristic (n=21,015) | Systolic BP | P Value | ||||
|---|---|---|---|---|---|---|
| ≤120 mmHg(n=5357) | 121–130 mmHg(n=4268) | 131–140 mmHg(n=4512) | 141–150 mmHg(n=3038) | >150 mmHg(n=3840) | ||
| Women | 54.0 | 58.6 | 62.5 | 63.8 | 67.1 | <0.001 |
| eGFR | <0.001 | |||||
| 45–59 ml/min per 1.73 m2 | 71.9 | 76.1 | 75.9 | 75.7 | 70.7 | |
| ≤44 ml/min per 1.73 m2 | 28.1 | 23.9 | 24.1 | 24.3 | 29.3 | |
| Age | <0.001 | |||||
| 65–70 (mean, 67.8±1.6) yr | 21.4 | 20.6 | 20.4 | 19.2 | 16.6 | |
| 71–80 (mean, 75.5±2.8) yr | 40.7 | 45.6 | 45.1 | 45.3 | 45.4 | |
| >80 (mean, 85.7± 4.0) yr | 38.0 | 33.8 | 34.6 | 35.6 | 38.0 | |
| Baseline diastolic BP | <0.001 | |||||
| ≤60 mmHg | 40.3 | 18.2 | 13.4 | 8.6 | 6.2 | |
| 61–80 mmHg | 56.9 | 71.0 | 68.8 | 62.4 | 51.6 | |
| 81–90 mmHg | 2.7 | 9.8 | 15.7 | 24.2 | 27.2 | |
| >90 mmHg | 0.1 | 1.0 | 2.1 | 4.8 | 15.0 | |
| Baseline pulse pressure | <0.001 | |||||
| >90 mmHg | 0 | 0 | 0.4 | 2.6 | 32.6 | |
| 71–90 mmHg | 0.7 | 5.2 | 21.3 | 44.2 | 52.0 | |
| 51–70 mmHg | 30.8 | 64.3 | 68.8 | 50.8 | 14.8 | |
| ≤50 mmHg | 68.5 | 30.5 | 9.6 | 2.4 | 0.6 | |
| Coronary artery disease | 42.6 | 32.9 | 28.8 | 28.0 | 27.1 | <0.001 |
| Heart failure | 35.3 | 23.2 | 19.5 | 17.3 | 16.5 | <0.001 |
| Peripheral vascular disease | 14.7 | 13.1 | 11.3 | 12.2 | 12.1 | <0.001 |
| Hypertension | 77.7 | 84.5 | 88.8 | 90.8 | 93.7 | <0.001 |
| Diabetes | 30.2 | 31.4 | 29.4 | 29.7 | 28.9 | 0.13 |
| Stroke | 11.3 | 10.4 | 8.8 | 8.4 | 8.7 | <0.001 |
| Combined vascular diseasea | 52.9 | 44.4 | 39.1 | 38.1 | 37.6 | <0.001 |
| Tobacco useb | 14.8 | 12.2 | 11.9 | 12.2 | 10.7 | <0.001 |
| Missing tobacco use data | 6.47 | 5.48 | 5.73 | 3.62 | 4.34 | |
| Proteinuria | 9.8 | 9.8 | 10.2 | 12.5 | 14.6 | <0.001 |
| Missing proteinuria data | 30.0 | 32.1 | 33.0 | 32.2 | 33.0 | |
| No. of antihypertensive agents at baseline | <0.001 | |||||
| 0 | 10.4 | 11.8 | 14.3 | 14.7 | 12.9 | |
| 1–2 | 44.7 | 47.1 | 48.2 | 45.2 | 43.7 | |
| ≥3 | 45.0 | 41.1 | 37.5 | 40.1 | 43.4 | |
| Body mass index | <0.001 | |||||
| ≤18.5 kg/m2 | 1.8 | 1.1 | 0.9 | 1.0 | 1.2 | |
| >18.5 and <30 kg/m2 | 58.9 | 56.8 | 54.8 | 55.0 | 57.0 | |
| ≥30 kg/m2 | 33.4 | 37.4 | 39.6 | 39.0 | 35.7 | |
| Missing BMI data | 5.9 | 4.7 | 4.7 | 5 | 6.2 | |
The values shown represent the percentage of individuals who have that characteristic within each systolic BP group. The characteristic of hypertension refers to patients with a diagnostic code for hypertension in their medical record. eGFR was estimated by the CKD-Epidemiology Collaboration formula. BMI, body mass index.
a
Combined vascular disease includes patients who had one or more of the following diagnostic codes: coronary artery disease, peripheral vascular disease, and stroke.
b
Tobacco use refers to patients with outpatient medical record documentation of smoking history up to 2 years before cohort entry.