Table 4.

Dose-effect relationship between eplerenone and change in serum potassium from baseline

Dose	Change in Serum Potassium Compared with Baseline, mEq/L (95% CI)
0 mg/d	Referent
25 mg three times per week	−0.25 (-0.54–0.05)
25 mg/d	0.05 (-0.09–0.20)
50 mg/d	0.21 (0.08–0.34)

Analysis was controlled for dialysate potassium concentration and baseline serum potassium using mixed-effects regression with eplerenone dose included as a time-varying fixed effect variable and patient included as a random effect. 95% CI, 95% confidence interval.