Table 2.
WT CHOW | WT HFD | LGALS3−/− CHOW | LGALS3−/− HFD | |
---|---|---|---|---|
ChREBP | 1.08 ± 0.02 | 1.3 ± 0.23 | 1.27 ± 0.19 | 1.39 ± 0.19 |
LXR-α | 1.02 ± 0.48 | 4.93 ± 0.95b | 1.31 ± 0.66 | 1.65 ± 0.62# |
LXR-β | 0.93 ± 0.40 | 1.79 ± 0.3b | 1.08 ± 0.27 | 1.42 ± 0.18 |
SREBP-1c | 1.02 ± 0.23 | 1.76 ± 0.15b | 0.89 ± 0.08 | 1.78 ± 0.23 |
PPAR-γ | 1.03 ± 0.61 | 2.52 ± 0.53b | 1.60 ± 0.50 | 5.57 ± 0.25b,c |
Abca-1 | 0.32 ± 0.10 | 1.87 ± 0.57b | 0.71 ± 0.30 | 4.87 ± 0.77b |
Cd36 | 0.70 ± 0.43 | 1.20 ± 0.72 | 0.98 ± 0.56 | 4.70 ± 0.49b,c |
FAS | 0.66 ± 0.13 | 0.83 ± 0.23 | 0.42 ± 0.09 | 2.21 ± 0.31b,c |
DAGT1 | 0.38 ± 0.12 | 1.64 ± 0.61b | 0.33 ± 0.07 | 1.05 ± 0.23b |
DAGT2 | 0.52 ± 0.22 | 3.15 ± 0.61b | 0.51 ± 0.11 | 2.50 ± 0.26b |
CPT1 | 0.51 ± 0.23 | 2.66 ± 0.87b | 0.77 ± 0.27 | 2.67 ± 0.91b |
Relative mRNA expression in liver was analyzed by qRT-PCR after 24 wks of HFD or standard diet feeding. The results are shown as the means ± SEM (n = 5–6 mice/group/experiment). The results are representative of two repeated experiments.
P < 0.05 versus CHOW-fed mice.
P < 0.05 versus WT mice.