Table 2.

Hepatic mRNA expression levels of genes involved in lipid metabolism.^a

	WT CHOW	WT HFD	LGALS3−/− CHOW	LGALS3−/− HFD
ChREBP	1.08 ± 0.02	1.3 ± 0.23	1.27 ± 0.19	1.39 ± 0.19
LXR-α	1.02 ± 0.48	4.93 ± 0.95b	1.31 ± 0.66	1.65 ± 0.62#
LXR-β	0.93 ± 0.40	1.79 ± 0.3b	1.08 ± 0.27	1.42 ± 0.18
SREBP-1c	1.02 ± 0.23	1.76 ± 0.15b	0.89 ± 0.08	1.78 ± 0.23
PPAR-γ	1.03 ± 0.61	2.52 ± 0.53b	1.60 ± 0.50	5.57 ± 0.25b,c
Abca-1	0.32 ± 0.10	1.87 ± 0.57b	0.71 ± 0.30	4.87 ± 0.77b
Cd36	0.70 ± 0.43	1.20 ± 0.72	0.98 ± 0.56	4.70 ± 0.49b,c
FAS	0.66 ± 0.13	0.83 ± 0.23	0.42 ± 0.09	2.21 ± 0.31b,c
DAGT1	0.38 ± 0.12	1.64 ± 0.61b	0.33 ± 0.07	1.05 ± 0.23b
DAGT2	0.52 ± 0.22	3.15 ± 0.61b	0.51 ± 0.11	2.50 ± 0.26b
CPT1	0.51 ± 0.23	2.66 ± 0.87b	0.77 ± 0.27	2.67 ± 0.91b

^aRelative mRNA expression in liver was analyzed by qRT-PCR after 24 wks of HFD or standard diet feeding. The results are shown as the means ± SEM (n = 5–6 mice/group/experiment). The results are representative of two repeated experiments.

^bP < 0.05 versus CHOW-fed mice.

^cP < 0.05 versus WT mice.