Table 3.

Summary of Outcomes With Nonoperative Versus Operative Management of LARC After CRT in High-Volume Centers

Reference	No. of cCRs	%	Mean Interval to LR (months)	No. of Patients	OS				DFS
					NOM		Operative Arm		NOM		Operative Arm
					Survival	%	Survival	%	Survival	%	Survival	%
Habr-Gama et al125	71	27	60	2	5-year	100	5-year	88	5-year	92	5-year	83
Habr-Gama et al126	90	49	17	28	5-year	91	N.A.		5-year	68	N.A.
Maas et al127	21	11	22	1	2-year	100	2-year	91	2-year	89	2-year	93
Smith et al128	32	N.A.	11	6	2-year	97	2-year	88	2-year	100	2-year	98

Abbreviations: cCR, clinical complete response; CRT, chemoradiotherapy; DFS, disease-free survival; LARC, locally advanced rectal cancer; LR, local recurrence; N.A., not available; NOM, nonoperative management; OS, overall survival; RT, radiotherapy;