Table 5.
Seropositivity rates for neutralizing antibody to each DENV type based on priming status (ATP cohort for immunogenicity)
| ATP cohort, primed, and unprimed subjects: N = 507 | ||||||
|---|---|---|---|---|---|---|
| Unprimed subjects | Primed Subjects | |||||
| Antibody | Group | Timing | N | % ≥ 1:10 (95% CI) | N | % ≥ 1:10 (95% CI) |
| DENV-1 | F17 | PRE | 86 | 0.0 (0.0–4.2) | 91 | 97.8 (92.3–99.7) |
| PI(M3) | 83 | 20.5 (12.4–30.8) | 88 | 97.7 (92.0–99.7) | ||
| PII(M7) | 82 | 95.1 (88.0–98.7) | 87 | 100 (95.8–100) | ||
| F19 | PRE | 61 | 0.0 (0.0–5.9) | 94 | 96.8 (91.0–99.3) | |
| PI(M3) | 60 | 26.7 (16.1–39.7) | 93 | 98.9 (94.2–100) | ||
| PII(M7) | 59 | 83.1 (71.0–91.6) | 90 | 100 (96.0–100) | ||
| DENV-2 | F17 | PRE | 86 | 0.0 (0.0–4.2) | 91 | 97.8 (92.3–99.7) |
| PI(M3) | 83 | 26.5 (17.4–37.3) | 88 | 96.6 (90.4–99.3) | ||
| PII(M7) | 82 | 89.0 (80.2–94.9) | 87 | 100 (95.8–100) | ||
| F19 | PRE | 61 | 0 (0.0–5.9) | 94 | 96.8 (91.0–99.3) | |
| PI(M3) | 60 | 43.3 (30.6–56.8) | 93 | 98.9 (94.2–100) | ||
| PII(M7) | 59 | 93.2 (83.5–98.1) | 90 | 98.9 (94.0–100) | ||
| DENV-3 | F17 | PRE | 86 | 0.0 (0.0–4.2) | 91 | 96.7 (90.7–99.3) |
| PI(M3) | 83 | 14.5 (7.7–23.9) | 88 | 96.6 (90.4–99.3) | ||
| PII(M7) | 82 | 92.7 (84.8–97.3) | 87 | 100 (95.8–100) | ||
| F19 | PRE | 61 | 0.0 (0.0–5.9) | 94 | 92.6 (85.3–97.0) | |
| PI(M3) | 60 | 21.7 (12.1–34.2) | 93 | 98.9 (94.2–100) | ||
| PII(M7) | 59 | 78.0 (65.3–87.7) | 90 | 98.9 (94.0–100) | ||
| DENV-4 | F17 | PRE | 86 | 0.0 (0.0–4.2) | 91 | 96.7 (90.7–99.3) |
| PI(M3) | 83 | 37.3 (27.0–48.7) | 88 | 98.9 (93.8–100) | ||
| PII(M7) | 82 | 97.6 (91.5–99.7) | 87 | 100 (95.8–100) | ||
| F19 | PRE | 61 | 0.0 (0.0–5.9) | 94 | 98.9 (94.2–100) | |
| PI(M3) | 60 | 26.7 (16.1–39.7) | 93 | 98.9 (94.2–100) | ||
| PII(M7) | 59 | 86.4 (75.0–94.0) | 90 | 98.9 (94.0–100) | ||
ATP = according to protocol; 95% CI = exact 95% confidence interval (lower and upper limits); DENV = dengue virus; N = number of subjects with available results; n/% = number/percentage of subjects with titer > = 1:10; PI(M3) = post-dose 1, Month 3 visit; PII(M7) = post-dose 2, Month 7 visit; PRE = pre-vaccination.