Table 4. The HRs of incident HU across the quartiles of Hct in male population.

	Quartile of baseline Hct				P for trend
	1(lowest)	2	3	4(highest)
Minimum follow-up = 1 year (33110 person-years)
Median (range)	39.8(<41.4)	42.5(41.4–43.5)	44.5(43.6–45.5)	46.9(>45.5)	–
No. of subjects	3669	3713	3461	3579	–
Person-years of follow-up	9422.5	8881.5	7727.5	7078.5	–
Incidence of HU (per 1000 person-years)	55.2	56.1	63.9	78.5	–
Unadjusted HR (95%CI)	1.00(reference)	1.01(0.89, 1.14)	1.13(1.00, 1.28)	1.36(1.21, 1.54)	0.00
P value	–	0.93	0.05	0.00
Age, BMI adjusted HR (95%CI)	1.00(reference)	0.95(0.84, 1.08)	1.04(0.92, 1.18)	1.22(1.08, 1.38)	0.00
P value	–	0.43	0.57	0.00	–
Multivariable adjusted HR (95%CI)	1.00(reference)	0.92(0.81, 1.04)	0.96(0.85, 1.10)	1.11(0.98, 1.26)	0.09
P value	–	0.17	0.57	0.11	–
Minimum follow-up = 2 years (31814 person-years)
Multivariable adjusted HR (95%CI)	1.00(reference)	0.90(0.79, 1.02)	0.98(0.86, 1.11)	1.13(0.99, 1.28)	0.04
P value		0.10	0.71	0.07
Minimum follow-up = 3 years (26441 person-years)
Multivariable adjusted HR (95%CI)	1.00(reference)	0.87(0.77, 0.99)	0.96(0.88, 1.13)	1.15(1.02, 1.31)	0.01
P value	–	0.04	0.96	0.03
Minimum follow-up = 4 years (20756 person-years)
Multivariable adjusted HR (95%CI)	1.00(reference)	0.94(0.83, 1.08)	1.09(0.95, 1.24)	1.40(1.23, 1.59)	0.00
P value	–	0.40	0.22	0.00	–

Hct, hematocrit; BMI, body mass index; No., number; HR, hazard ratio.

Multivariable adjusted model included: age, sex (male or female), BMI (≥25 or <25), white blood cell count, platelet count, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride (log-transformed), alanine aminotransferase (log-transformed), Estimated glomerular filtration rate (eGFR), fasting blood glucose (log-transformed), systolic pressure and diastolic pressure.