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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Sleep Med Clin. 2015 Jul 15;10(3):207–214. doi: 10.1016/j.jsmc.2015.05.022

Fig. 2.

Fig. 2

RLS CSF samples show 3-OMD is increased and correlated with increased HVA. Top right panel shows increase in 2 separate sets of RLS patients for samples from evening and morning. Left panel shows metabolic pathways for levodopa to 3-OMD and HVA. Bottom right panel shows correlation of these 2 metabolites of levodopa from different metabolic pathways. The values correlate for both metabolites indicating likely increased levodopa rather than abnormalities in the 2 different metabolic pathways. These data are compatible with the autopsy data showing increased tyrosine hydroxylase in the substantia nigra. (Adapted from Allen RP, Connor JR, Hyland K, et al. Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis. Sleep Med 2009;10(1):124, 127; with permission.)