Fig. 4. Necrotic fraction and microvessel density of VX2 liver tumor at 24-hour follow-up after CKD-516 treatment.

Histologic specimen (H&E stain, × 1) (A) and H&E stain, × 4 (B) shows large central necrosis and peripheral viable tumor tissue with necrotic fraction score of 2. In figure A, outer line indicates tumor border and inner line indicates margin of intratumoral necrotic portion. CD31 staining of same specimen shows compact tumor cells and sparse microvessels (C). H&E = hematoxylin and eosin