Table 2. Relative Changes in DCE-MRI Parameters of Two Contrast Agent Groups in 24-Hour Follow-Up Studies.
| DCE-MRI Parameters | P792 (n = 7) | Gd-DOTA (n = 6) | P* |
|---|---|---|---|
| Ktrans (min-1) | |||
| Baseline | 0.09 ± 0.07 (0.04, 0.2) | 0.12 ± 0.04 (0.06, 0.19) | 0.226 |
| 4 hours | 0.04 ± 0.02 (0.02, 0.06) | 0.08 ± 0.05 (0.04, 0.13) | 0.022 |
| 24 hours | 0.02 ± 0.01 (0.004, 0.05) | 0.08 ± 0.04 (0.02, 0.13) | 0.022 |
| ΔKtrans (%) | |||
| 4 hours | -54.72 ± 24.33 (-68.32, 11.11) | -30.14 ± 3.07 (-44.86, -20.55) | 0.174 |
| 24 hours | -76.42 ± 9.09 (-91.3, -13.89) | -40.26 ± 17.46 (-60, -21.5) | 0.038 |
| iAUC (mmol/sec) | |||
| Baseline | 6.78 ± 5.84 (3.45, 11.92) | 10.04 ± 5.26 (6.89, 18.38) | 0.134 |
| 4 hours | 4.94 ± 2.12 (1.51, 6.18) | 9.55 ± 3.07 (2.62, 12) | 0.032 |
| 24 hours | 2.16 ± 1.8 (0.16, 3.82) | 7.75 ± 5.32 (4.67, 12.4) | 0.008 |
| ΔiAUC (%) | |||
| 4 hours | -45.97 ± 25.63 (-72.08, 30.62) | -32.53 ± 25.04 (-33.95, 6.01) | 0.134 |
| 24 hours | -76.17 ± 16.88 (-95.79, 9.92) | -21.93 ± 29.16 (-62.02, 26.53) | 0.027 |
Data are expressed as median ± interquartile range and data in parentheses indicate ranges. *Mann-Whitney U test. DCE-MRI = dynamic contrast-enhanced magnetic resonance imaging, Gd-DOTA = gadoterate meglumine, iAUC = initial area under gadolinium concentration-time curve until 60 seconds