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. 2015 Sep 4;5:13598. doi: 10.1038/srep13598

Table 1. Study characteristics from included studies in the meta-analysis.

First author Year Country Ethnicity Cases
 Controls
 Criteria for AD diagnosis Time of AD onset Control type Quality score
Na Ageb Agec Genderd N Ageb Genderd
Dahiyat M -1 1999 UK Caucasian 260 57.0 79.8 35.6 207 71.0 47.1 NINCDS/ADRDA Mixed PB 10
Dahiyat M -2 1999 UK Caucasian 179 74.0 82.0 51.4 186 77.0 50.0 NINCDS/ADRDA Late PB 10
Crawford F 2000 USA Caucasian 287 73.0 — 33.0 120 73.3 42.0 NINCDS/ADRDA Late PB 8
Higuchi S 2000 Japan Asian 411 — 76.0 27.3 350 75.7 27.7 NINCDS/ADRDA Mixed PB 10
Kunugi H 2000 Japan Asian 172 — 74.1 34.3 165 57.0 41.2 NINCDS/ADRDA Mixed HB 6
Emahazion T 2001 Scotland Caucasian 121 — — — 152 — — NINCDS/ADRDA Early PB 11
Sanchez-Guerra M 2001 Spain Caucasian 301 71.5 75.2 34.0 309 80.3 29.0 NINCDS/ADRDA Mixed HB 7
Singleton A 2001 UK Caucasian 212 79.8 — 33.3 106 78.2 47.6 NINCDS/ADRDA Late PB 9
Tedde A 2002 Italy Caucasian 220 65.0 — 36.4 95 80.8 42.1 DSM-IV Mixed PB 9
Kalman J 2003 Hungary Caucasian 51 — 76.0 31.4 51 72.0 47.1 NINCDS/ADRDA DSM-III Late PB 7
Monastero R 2003 Italy Caucasian 149 69.7 72.0 38.5 149 73.3 38.5 NINCDS/ADRDA Mixed PB 10
Yang Z 2004 China Asian 68 72.8 — 38.2 158 71.2 50.0 NINCDS/ADRDA DSM-III Late PB 11
Blomqvist ME 2005 Sweden Caucasian 382 76.2 — 37.1 170 73.2 46.7 NINCDS/ADRDA Mixed HB 7
Guidi I 2005 Italy Caucasian 405 73.0 — 29.6 253 71.0 42.3 NINCDS/ADRDA Mixed HB 8
Akomolafe A -1 2006 USA Caucasian 235 — 71.4 24.0 82 72.3 30.0 NINCDS/ADRDA Mixed PB 13
Akomolafe A -2 2006 Mixede Caucasian 259 — 68.3 34.0 127 71.7 59.0 NINCDS/ADRDA Mixed PB 10
Zhou Y 2006 China Asian 530 — 71.3 63.0 601 71.5 55.9 NINCDS/ADRDA DSM-IV Mixed PB 9
Li H 2008 Canada Caucasian 688 77.8 71.9 42.4 681 73.4 35.6 NINCDS/ADRDA Mixed PB 15
Styczynska M 2008 Poland Caucasian 154 — 71.5 33.8 176 72.7 31.8 NINCDS/ADRDA Late PB 11
Wang B 2008 China Asian 338 77.6 — 51.0 378 72.9 58.0 NINCDS/ADRDA DSM-III Late PB 11
Giedraitis V 2009 Sweden Caucasian 79 — 80.2 100 361 81.8 100 NINCDS/ADRDA DSM- IV Late PB 10
Azizi Z 2010 Iran Asian 100 73.8 — 44.0 100 72.6 48.0 NINCDS/ADRDA Late PB 9
Ferlazzo N 2011 Italy Caucasian 69 77.2   42.0 69 75.6 34.8 NINCDS/ADRDA Early PB 10

DSM: the Diagnostic and Statistical Manual of Mental Disorders; NINCDS: the National Institute of Neurological Disorders and Stoke; ADRDA: Alzheimer Diseases and Related Disorders Association; MMSE: mini-mental state examination; NA: not applicable; SNP: Single Nucleotide Polymorphism; PB = population based control; HB = hospital based control.

aNumber.

bage at survey.

cage at onset of Alzheimer’s disease.

dpercentage of male.

eparticipants from four countries (Canada, Germany and Greece).