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Pharmacokinetic parameters of NB-360 after oral and intravenous application in mouse, rat and beagle dog
| Parameter | Mouse | Rat | Dog |
|---|---|---|---|
| Dose i.v. (μmol/kg) | 2 | 2 | 2 |
| Dose p.o. (μmol/kg) | 6 | 6 | 2 |
| Clearance after i.v. application (ml/min/kg) | 16 | 52 | 0.4 |
| Terminal half-life after i.v. application (hours) | 3.6 | 2.7 | 36.2 |
| Vol. of Distribution (l/kg) | 4.6 | 10.2 | 0.9 |
| Oral Bioavailability (%) | 37 | 92 | 62 |
