Table 2.
MMP and TIMP activities in the follicular fluid between high and low oocyte maturity groups
| High oocyte maturity group (MII oocytes = 100 %) | Low oocyte maturity group (MII oocytes < 100 %) | P value | |
|---|---|---|---|
| Number of patients | 95 | 55 | |
| Estradiol (pg/ml) | 2774 ± 1078 | 2651 ± 1829 | NS |
| Progesterone (ng/ml) | 0.81 ± 0.78 | 0.69 ± 0.39 | NS |
| MII oocytes ratio (%) | 100 ± 0 | 76.4 ± 15.8 | < 0.001 |
| 2PN embryos ratio (%) | 75.9 ± 24.4 | 68.8 ± 23.8 | NS |
| D5 GB embryos ratio (%) | 45.8 ± 32.5 | 29.8 ± 33.5 | < 0.01 |
| MMP-2 (Arbitrary units/μl) | 19.6 ± 4.3 | 16.3 ± 4.3 | < 0.001 |
| MMP-9 (Arbitrary units/μl) | 2.11 ± 0.59 | 2.19 ± 0.74 | NS |
| TIMP-1 (ng/ml) | 123 ± 37 | 107 ± 26 | NS |
| TIMP-2 (ng/ml) | 54.6 ± 16.5 | 52.6 ± 13.6 | NS |
MII Metaphase II, 2PN Two pronuclei, D5 GB Good-quality blastocysts on day 5, MMP Matrix metalloproteinase, TIMP Tissue inhibitor of matrix metalloproteinase
Values are expressed as the mean ± SD. P values are comparisons between the high- and low-maturity groups by ANOVA.; NS: no statistical significance (i.e., P > 0.05)