Table 3.
MMP and TIMP activities in the follicular fluid between the high and low percentage successful fertilization groups
| High fertility rate group (2PN ≥ 70 %) | Low fertility rate group (2PN < 70 %) | P value | |
|---|---|---|---|
| Number of patients | 84 | 66 | |
| Estradiol (pg/ml) | 2689 ± 1588 | 2707 ± 1611 | NS |
| Progesterone (ng/ml) | 0.72 ± 0.49 | 0.74 ± 0.60 | NS |
| MII oocytes ratio (%) | 95.2 ± 11.9 | 88.3 ± 16.3 | < 0.01 |
| 2PN embryos ratio (%) | 88.5 ± 11.0 | 49.6 ± 18.1 | < 0.001 |
| D5 GB embryos ratio (%) | 42.8 ± 33.4 | 26.6 ± 32.5 | < 0.01 |
| MMP-2 (Arbitrary units/μl) | 19.4 ± 4.2 | 17.5 ± 4.6 | < 0.01 |
| MMP-9 (Arbitrary units/μl) | 2.14 ± 0.70 | 2.10 ± 0.59 | NS |
| TIMP-1 (ng/ml) | 117 ± 32 | 120 ± 35 | NS |
| TIMP-2 (ng/ml) | 55.1 ± 15.1 | 53.2 ± 17.0 | NS |
MII Metaphase II, 2PN Two pronuclei, D5 GB Good-quality blastocysts on day 5, MMP Matrix metalloproteinase, TIMP Tissue inhibitor of matrix metalloproteinase
Values are expressed as the mean ± SD. P values are comparisons between the high and low percentage successful fertilization groups by ANOVA. NS: no statistical significance (i.e., P > 0.05)