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Table 3.

Results of enforced expression of AKR1C3 in ALL-11 xenografted mice and treatment with PR-104 at 200 mg/kg for 2 weeks

Treatment EFS, d LGD, d P value PR-104 vs vehicle Median ORM Overall response
Untransduced Vehicle 10.1
ALL-11 PR-104 27.2 17.1 .014 6 PR
Empty vector Vehicle 12.9
control PR-104 31.3 18.4 <.0001 6 PR
AKR1C3 Vehicle 12.8
cDNA PR-104 55.8 43.0 <.0001 9 CR

CR, complete response; EFS, event-free survival; LGD, leukemia growth delay; PR, partial response.