Table 2.
Association between organochlorine insecticides and risk of metastatic prostate cancer in the Janus cohort.
| Metabolite | Continuous | Q1 | Q2 vs. Q1 | Q3 vs. Q1 | Q4 vs. Q1 | p-Trendc | |||
|---|---|---|---|---|---|---|---|---|---|
| ORa,b (95% CI) | Ca/Co | Ca/Co | ORb (95% CI) | Ca/Co | ORb (95% CI) | Ca/Co | ORb (95% CI) | ||
| Chlordane | 1.09 (0.96, 1.24) | 31/77 | 33/76 | 1.01 (0.52, 1.94) | 44/81 | 1.39 (0.73, 2.62) | 42/80 | 1.65 (0.82, 3.34) | 0.13 |
| Oxychlordane | 1.26 (0.97, 1.64) | 30/79 | 36/78 | 1.35 (0.70, 2.59) | 37/79 | 1.34 (0.70, 2.55) | 46/78 | 2.03 (1.03, 4.03) | 0.05 |
| trans-Nonachlor | 1.29 (0.80, 2.08) | 39/79 | 31/78 | 0.79 (0.43, 1.44) | 35/79 | 0.89 (0.49, 1.63) | 45/78 | 1.38 (0.73, 2.61) | 0.19 |
| Heptachlor epoxide | 1.08 (0.82, 1.42) | 32/78 | 33/79 | 1.01 (0.50, 2.02) | 32/78 | 1.19 (0.60, 2.36) | 52/79 | 2.01 (0.98, 4.10) | 0.05 |
| DDT | 0.98 (0.88, 1.10) | 34/79 | 36/78 | 0.94 (0.50, 1.78) | 43/79 | 1.07 (0.59, 1.94) | 37/78 | 0.97 (0.50, 1.88) | 0.99 |
| p,p’-DDT | 0.97 (0.69, 1.38) | 39/79 | 35/78 | 0.86 (0.46, 1.60) | 33/79 | 0.76 (0.39, 1.47) | 43/78 | 1.01 (0.52, 1.99) | 0.75 |
| p,p’-DDE | 0.96 (0.72, 1.29) | 35/79 | 32/78 | 0.80 (0.42, 1.51) | 47/79 | 1.23 (0.69, 2.21) | 36/78 | 0.90 (0.47, 1.73) | 0.99 |
| o,p’-DDT | 0.96 (0.71, 1.28) | 42/79 | 34/78 | 0.75 (0.41, 1.38) | 27/79 | 0.62 (0.33, 1.19) | 47/78 | 0.99 (0.50, 1.97) | 0.58 |
| Hexachlorobenzene | 1.21 (0.75, 1.97) | 29/79 | 49/78 | 1.70 (0.90, 3.22) | 34/79 | 1.35 (0.62, 2.93) | 38/78 | 2.03 (0.86, 4.84) | 0.22 |
| γ‑Hexachlorocyclohexane | 1.01 (0.81, 1.26) | 41/79 | 33/78 | 0.79 (0.42, 1.47) | 31/79 | 0.80 (0.41, 1.56) | 45/78 | 1.10 (0.57, 2.12) | 0.67 |
| β‑Hexachlorocyclohexane | 1.19 (0.72, 1.95) | 34/78 | 37/79 | 1.05 (0.56, 1.97) | 29/79 | 0.75 (0.38, 1.50) | 50/78 | 1.44 (0.71, 2.94) | 0.29 |
| Dieldrin | 1.07 (0.87, 1.31) | 32/78 | 37/77 | 1.14 (0.61, 2.15) | 30/79 | 0.92 (0.46, 1.84) | 50/80 | 1.42 (0.73, 2.77) | 0.29 |
| Mirex | 1.26 (0.96, 1.65) | 36/78 | 35/79 | 1.01 (0.55, 1.86) | 34/79 | 0.94 (0.50, 1.77) | 44/78 | 1.73 (0.90, 3.31) | 0.07 |
| Abbreviations: Ca/Co, cases/controls; DDE, dichlorodiphenyldichloroethylene; DDT, dichlorodiphenyltrichloroethane; OR, odds ratio; Q, quartile. aPer unit increase in natural log–transformed ng/g lipid. bAdjusted for county, age at collection, and date at collection. cTrend of median values across quartiles. | |||||||||