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Phase 2 study. HE histology (original magnification, × 200) shows normal collagen fibril density under the epidermis layer in (A), obtained from saline-treated rats underwent OVX. Both in gadodiamide only (B) and in gadodiamide + OVX -treated rats (C), -treated rats, spindle cell and stellate cell hyperplasia were found, resulting in denser collagen fibril. OVX, ovariectomy.
