Table 1. Cellularity and epidermal thickness of rats treated with saline, gadoteric acid, and gadodiamide in phase 1 study.

Study group	Cellularity/×200 view*	Epidermis thickness (µm)**
Baseline	89±10	22±4
Saline	90±7	25±5
Gadoteric acid	104±10#	33±4∆
Gadodiamide	120±9§	46±9∆

*, 8 rats × 5 fields = 40 counts; **, 8 rats × 10 fields = 80 counts. Cellularity was defined by the number of spindle cells and stellate cells under the epidermis layer per vision field (×200). Cellularity: ^#, P=0.002 vs. saline group; ^§, P<0.0001 vs. saline group; gadodiamide group vs. gadoteric acid group P=0.001. Epidermis thickness (∆), saline vs. gadoteric acid; gadoteric acid vs. gadodiamide, both <0.001.