Table 2. Cellularity and epidermis thickness of rats treated with saline + OVX, gadodiamide only, and gadodiamide + OVX in phase 2 study.

Study group	Cellularity/× 200 view*	Epidermis thickness (µm)**
Baseline	94±7	24±2
Saline + OVX	101±4	26±2
Gadodiamide	126±8 §	41±3 §
Gadodiamide + OVX	124±6 §	39±5 §

*, 8 rats × 5 fields =40 counts; **, 8 rats × 10 fields =80 counts. Cellularity was defined by the number of spindle cells and stellate cells under the epidermis layer per vision field (×200). ^§, P<0.001 vs. saline group; P>0.05 gadodiamide group vs. gadodiamide + OVX group. OVX, ovariectomy.