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. 2015 Sep 4;9:352. doi: 10.3389/fncel.2015.00352

Figure 2.

Figure 2

The effects of P2X7R agonist and antagonist on PARP1 expression in astrocytes within the molecular layer of the dentate gyrus 1 week after SE. As compared to non-SE animals (A), vehicle-treated animals show the astroglial loss in the molecular layer of the dentate gyrus accompanied by reduction of PARP1 expression (B). BzATP deteriorates astroglial death and astroglial PARP1 degradation following SE (C). Both OxATP and A740003 effectively prevent astroglial death with the preservation of astroglial PARP1 expression (D,E). Insertions (in A,D,E) are high magnification of rectangles. Bar = 50 and 25 (insertion) μm. (F) The fraction of PARP1 positive astrocytes in the total number of astrocytes within the molecular layer of the dentate gyrus (means ± s.d., n = 5, respectively). *p < 0.05 vs. non-SE animals (one-way ANOVA test).