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. 2015 Sep 4;9:352. doi: 10.3389/fncel.2015.00352

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Copyright © 2015 Kim, Ko and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of P2X7R agonist and antagonist on PARP1 activity in the molecular layer of the dentate gyrus 1 week after SE. PAR synthesis is detected only in dentate granule cells (A,B). BzATP does not affect astroglial PAR synthesis induced by SE (C). Both OxATP and A740003 increase astroglial PAR expression following SE (D,E). Bar = 50 μm. (F) The fraction of PAR positive astrocytes in the total number of astrocytes within the molecular layer of the dentate gyrus (means ± s.d., n = 5, respectively). *p < 0.05 vs. non-SE animals (one-way ANOVA test).