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. 2015 Sep 4;9:352. doi: 10.3389/fncel.2015.00352

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Copyright © 2015 Kim, Ko and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of P2X7R agonist and antagonist on clasmatodendrosis in the stratum radiatum of the CA1 region 4 weeks after SE. SE induces lysosomal-associated membrane protein-1 (LAMP1) positive clasmatodendrosis in the CA1 region (A,B). BzATP effectively reduces the number of LAMP1 positive clasmatodendritic astrocytes (C). Both OxATP and A490003 aggravate LAMP1 positive clasmatodendrosis (D,E). Bar = 25 μm. (F) The fraction of LAMP1 positive astrocytes in the total number of astrocytes within the CA1 region (means ± s.d., n = 5, respectively). *p < 0.05 vs. non-SE animals (one-way ANOVA test).