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The effects of P2X7R agonist and antagonist on astroglial PARP1 expression in the stratum radiatum of the CA1 region 4 weeks after SE. PARP1 expression is rarely detected in astrocytes of non-SE animals (A). Following SE, PARP1 expression is observed in reactive astrocytes (B), not in clasmatodendritic astrocytes (C). BzATP increases PARP1 expression in reactive astrocytes (D). Both OxATP and A740003 cannot induce PARP1 expression in clasmatodendritic astrocytes (E,F). Bar = 12.5 μm.
