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. 2015 Sep 4;9:352. doi: 10.3389/fncel.2015.00352

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Copyright © 2015 Kim, Ko and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of P2X7R agonist and antagonist on astroglial PARP1 activity in the stratum radiatum of the CA1 region 4 weeks after SE. PAR synthesis is rarely detected in astrocytes of non-SE animals (A). Following SE, PAR synthesis is observed in clasmatodendritic astrocytes (B). BzATP inhibits PAR synthesis in astrocytes. Both OxATP and A740003 increase the number of PAR positive astrocytes (C–E). Bar = 25 μm. (F) The fraction of PAR positive astrocytes in the total number of astrocytes within the CA1 region (means ± s.d., n = 5, respectively). *p < 0.05 vs. non-SE animals (one-way ANOVA test).