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. 2015 Sep 4;9:352. doi: 10.3389/fncel.2015.00352

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Copyright © 2015 Kim, Ko and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of P2X7R agonist and antagonist on PARP1 activity in reactive astrocytes within the molecular layer of the dentate gyrus 4 weeks after SE. PAR-positive astrocytes are not observed in the molecular layer within the dentate gyrus of non-SE (A), vehicle-treated (B) and BzATP-treated (C) animals. Both OxATP and A740003 increase the number of PAR positive astrocytes in the molecular layer of the dentate gyrus (D,E). Bar = 50 μm. (F) The fraction of PAR positive astrocytes in the total number of astrocytes within the molecular layer of the dentate gyrus (means ± s.d., n = 5, respectively). *p < 0.05 vs. non-SE animals (one-way ANOVA test).