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The effects of PARP1 inhibitors (DPQ and PJ-34) on LAMP1 or PAR positive astroglial responses in the stratum radiatum of the CA1 region 4 weeks after SE. Both PARP1 inhibitors reduce LAMP1 positive clasmatodendrosis (A–C) and PAR synthesis (D–F), as compared to vehicle. (G) The numbers of clasmatodendritic and PAR-positive astrocytes in the stratum radiatum of the CA1 region (means ± s.d., n = 5, respectively). *p < 0.05 vs. vehicle-treated animals (one-way ANOVA test). Bar = 50 μm.
