Fig. 7.

Administering a mAb directed against Slamf6 ameliorates C. rodentium-induced colitis in Rag ^−/− mice. (A) Infection and treatment diagram for Rag ^−/− mice that were intra-peritoneally injected with 100 µg anti-Slamf6 mAb (330) 1 day prior to infection and subsequently every seventh day after the first injection. Control mice were injected with 100 µg mouse IgG2a in the same regimen. (B) The weight of individual mice was measured every 4 days and represented as a percentage of their weight on the day of infection. (C) Survival of infected anti-Slamf6 mAb-treated and isotype-treated Rag ^−/− mice. (D) C. rodentium counts in fecal pellets that were obtained directly from mice every 3 days. Serial dilutions were made in PBS and plated on MacConkey plates. Counted bacterial colonies are represented as CFU per g feces.