Table 1.
Slamf receptors and their adaptor SAP modulate susceptibility to microbes
| Expression | Receptor deficiency results in resistance to: | Receptor deficiency results in susceptibility to: | Slamf ligand | Microbial ligand | |
|---|---|---|---|---|---|
| Slamf1, SLAM, CD150 | T, B, mono, Mø, DC, plat, HSC | Trypanosoma cruzi | Gram− bacteria, Leishmania major | Slamf1 | Measles virus E. coli (OmpC/F+) S. typhimurium |
| Slamf2, CD48 | Pan-lymphocyte | S. aureus | FimH+ enterobacterae | Slamf4, CD2 | E. coli (FimH+) |
| Slamf3, Ly-9, CD229 | T, B, iCD8, NKT, mono, Mø, HSC | Slamf3 | — | ||
| Slamf4, 2B4, CD244 | NK, NKT, T, B, γδ, CD8, DC, eo | LCMV, γHV-68 | Slamf2 | — | |
| Slamf5, CD84 | Pan-lymphocyte, plat, mast, eo | Slamf5 | — | ||
| Slamf6, NTB-A, Ly-108 | NK, NKT, T, B, Mø, pDC, Neu | Leishmania mexicana, C. rodentium | S. typhimurium | Slamf6 | E. coli, C. rodentium |
| Slamf7, CRACC, CS1, CD319 | T, B, mono, DC, NK | Slamf7 | — | ||
| Slamf8, BLAME | iCD8, mono, DC, Mø, Neu, endo, FRC | Slamf8 | — | ||
| Slamf9, SF2001 | T, B, mono, DC | ??? | — | ||
| SAP | NK, NKT, T, (B?) | Mouse: γHV-68, LCMV, Influenza Human: EBV, some other viruses |
Slamf1, 3, 4, 5, 6 Human only: Slamf7 |
N/A |
γHV-68, murine gamma-herpes virus 68; EBV, Epstein–Barr virus; FimH, bacterial lectin; LCMV, lymphocytic choriomengitis virus; SAP, Sh2d1a, Slam-associated protein.