Table 2.
Indices of RV diastolic function
| Baseline | Esmolol | Dobutamine | Volume | Endotoxin (early) | Endotoxin (late) | |
|---|---|---|---|---|---|---|
| Diastolic haemodynamic data | ||||||
| Heart rate (b.p.m.) | 92 (86–99) | 85 (78–91)* | 118 (111–125)* | 99 (92–106) | 89 (82–96) | 114 (107–121)* |
| Filling time (ms) | 274 (244–303) | 319 (290–349)* | 215 (184–245)* | 208 (177–239)* | 261 (231–291) | 166 (136–196)* |
| IVRT (ms) | 37 (30–43) | 43 (36–49) | 35 (27–42) | 39 (31–46) | 57 (50–64)* | 57 (50–64)* |
| -dP/dtmin (mmHg/s) | −416 (−477 to −355) | −412 (−473 to −350) | −605 (−670 to −540)* | −470 (−538 to −403) | −554 (−617 to −492)* | −588 (−651 to −525)* |
| Diastolic properties | ||||||
| τ (ms) | 41 (35–47) | 38 (33–44) | 29 (23–35)* | 65 (58–71)* | 40 (34–46) | 46 (40–51) |
| V0 (mL) | 30 (25–36) | 29 (23–34) | 27 (22–33) | 31 (26–37) | 32 (26–37) | 45 (40–51)* |
| S− (mmHg) | 7.9 (5.6–10.2) | 8.4 (6.0–10.7) | 5.7 (3.1–8.3) | 10.5 (7.7–13.2) | 8.6 (6.1–11) | 13 (10.6–15.5)* |
| Vd (mL) | 2 (0–3) | 2 (0–3) | 3 (2–5) | 8 (6–10)* | 2 (1–4) | 3 (2–5) |
| S+ (mmHg) | 11.1 (8.9–13.3) | 14.2 (12.0–16.5)* | 9 (6.5–11.5) | 23.1 (20.4–25.9)* | 11 (8.7–13.4) | 8.1 (5.7–10.5) |
| Vm (mL) | 71 (60–81) | 75 (65–86) | 69 (58–79) | 87 (75–98)* | 73 (62–83) | 79 (68–89) |
| dP/dV at V0 (mmHg/mL) | 0.29 (0.22–0.35) | 0.32 (0.25–0.39) | 0.24 (0.16–0.31) | 0.52 (0.44–0.60)* | 0.29 (0.22–0.36) | 0.28 (0.21–0.36) |
IVRT, isovolumic relaxation time; dP/dtmin, minimal derivative of RV pressure with respect to time; τ, time-constant of relaxation; V0, RV volume at zero passive pressure; S−, constant of diastolic elastic recoil; S+, constant of passive stiffness; Vm, RV maximal achievable volume; Vd, RV minimum dead volume; dP/dV at V0, derivative of RV pressure with respect to volume at V0.
*P < 0.05 vs. baseline.